You can buy Orlistat (Xenical/Alli) as an over-the-counter alternative to Wegovy in the UK.
However, Orlistat is a very different type of weight-loss medication, and research suggests it’s not as effective as Wegovy in supporting weight loss.
Wegovy and Orlistat are weight-loss medications approved for use in the UK. However, they are different medications with distinct dosing schedules, costs, and mechanisms of action on the body.
Orlistat is a lipase inhibitor. Lipases are gut enzymes that break down fat from food, enabling the gut to transport fat into the body to be burnt for energy or stored in our fat cells for later use.
Orlistat blocks lipases, preventing some of the dietary fat from our meals from being digested. This leads to fewer calories being absorbed, which can support weight loss.
Orlistat is a prescription medication produced by two pharmaceutical companies in the UK:
Wegovy is a weight-loss jab manufactured by Novo Nordisk. It’s a weekly weight-loss injection with semaglutide as the active ingredient.
Semaglutide is a that helps reduce hunger and appetite, allowing you to eat fewer calories, lose weight, and manage your blood sugar levels.
Wegovy is approved in the UK for individuals living with obesity to help them eat fewer calories and lose weight.
The over-the-counter version of Orlistat will cost around £18 a month, so it’s a very affordable medication.
In comparison, buying Wegovy and the injectable pens required for four weeks from Second Nature will cost £229 a month, rising to £299.
Orlistat is an affordable medication that is generally well-tolerated. However, it’s less effective than Wegovy. Wegovy is twice as effective as Orlistat for weight loss after one year.
So, if you’re looking for the most affordable weight-loss pill you can purchase over the counter, then Orlistat could be an option.
However, if you have a higher budget and are looking for the most effective weight-loss injection in the UK, semaglutide is a better choice.
Semaglutide is designed as an additional tool for weight management and, in most cases, shouldn’t be considered a lifelong medication.
Instead, it should be used to help you kickstart your weight loss and healthy journey while you commit to living a healthier lifestyle.
Ideally, we’d be able to lose weight without medication and lifestyle changes would be enough to support weight loss in the long term.
We’d generally recommend trying Second Nature’s before considering a weight-loss jab.
Changing your habits is the most sustainable way to achieve long-term weight loss, and it’s also less expensive.
At Second Nature, we’ve been trusted by the NHS since 2017 to support people with type 2 diabetes and obesity to lose weight, manage their blood sugar levels, and lead healthier lifestyles for the long term.
In 2022, the NHS in the BMJ that compared the weight loss outcomes of five providers in the National Diabetes Prevention Programme.
Second Nature was more than twice as effective at supporting weight loss than the other four providers.
However, if you’ve decided to try semaglutide (when it’s available) but need support in making positive changes to your lifestyle, Second Nature could be an option for you. But it’s worth noting that we have strict eligibility criteria.
Second Nature has (among the most commonly asked questions about weight loss medications):Dietary fats are large molecules that need to be broken down before they can be absorbed into the body. They are broken down by enzymes called lipases. That is, lipases play an important role in the digestion of dietary fat. When taken with a meal, Xenical interferes with the activity of these enzymes. This allows about 30% of the fat eaten in the meal to pass through the gut undigested. Therefore, your body cannot store these excess calories as fatty tissue or use them as a source of energy. This helps you to reduce your weight by burning up fat that you are already carrying, maintain your lower weight and minimise any weight regain. Losing even small amounts of weight and keeping it off produces additional health benefits for you, especially when you are at risk for other diseases such as heart disease and diabetes. Xenical can also help to improve risk factors, such as high blood pressure, high cholesterol and high blood sugar. If these are not treated, they could lead to other diseases such as hypertension and diabetes. Xenical should be taken in conjunction with a well-balanced calorie-controlled diet and other appropriate measures such as exercise.Active Ingredients:Xenical does not contain sucrose, gluten, tartrazine or any other azo dyes. Active ingredient - orlistat each Xenical capsule contains 120 mg orlistatInactive ingredients
DirectionsTake 1 capsule with each of the 3 main meals per day. It can be taken during the meal or up to 1 hour after the meal is consumed.Warnings & Disclaimers
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Xenical (orlistat) is a prescription medication designed to assist in weight loss. It's typically prescribed to individuals with obesity who haven't achieved their weight loss goals through diet and exercise alone. This drug is approved for use in adults under two specific conditions:
Xenical works by interfering with the body's ability to absorb fat from the diet, thereby reducing calorie intake. It is meant to be taken orally, three times a day, with each fat-containing meal. This approach emphasizes the importance of combining the medication with a healthy diet and regular exercise for more effective weight loss.
Xenical operates by targeting enzymes in the body known as "lipases." These enzymes are responsible for breaking down dietary fats into smaller components that the body can absorb for energy and storage. When taking Xenical, it inhibits the action of these lipases in the stomach and intestine. This inhibition prevents the complete breakdown and absorption of some fats, leading to their elimination through bowel movements instead of being stored in the body. Consequently, this process contributes to weight loss over time.
An important aspect of Xenical's mechanism is its impact on the absorption of fat-soluble vitamins. Since it reduces fat absorption, it can also reduce the intake of vitamins that are typically absorbed alongside fats. Therefore, patients using Xenical are advised to supplement their diet with a multivitamin containing fat-soluble vitamins. To ensure proper vitamin absorption, the multivitamin should be taken at least two hours before or after taking Xenical. This precaution helps maintain an adequate level of essential nutrients while using the medication.
Xenical has been shown to enhance weight loss when used in conjunction with a reduced-calorie diet, more effectively than dieting alone. Research indicates that over 20% of individuals using Xenical, alongside dietary changes, lose at least 5% of their body weight. In some cases, more than 15% of users even experience a loss of at least 10% of their body weight.
However, weight regain can occur once the medication is discontinued. This highlights the importance of continuing a balanced diet and regular exercise regimen even after stopping Xenical. The medication should be viewed as an initial boost in a weight loss journey, rather than a long-term solution. Sustainable weight management relies on ongoing lifestyle changes, including healthy eating and physical activity.
Xenical is known to have common side effects, primarily due to its mechanism of reducing fat absorption. These side effects are mostly related to the presence of unabsorbed fats in the intestines and stools. The typical side effects experienced by users of Xenical include:
It's important to note that these side effects are the primary reason for some users discontinuing Xenical. Over 20% of individuals may experience these side effects in the first year of use. However, the incidence of these side effects tends to decrease significantly if the medication is continued into a second year. This reduction over time may be due to the body's adaptation to the drug or adjustments in dietary habits in response to the medication's effects.
At a typical pharmacy, the cost of a 3-month supply of Xenical is about $780. However, there is also an over-the-counter version of Xenical, called. This medication contains a lower dose of orlistat but is less expensive and does not require a prescription.
Xenical is available in both generic and brand-name versions. For those that prefer the generic version, it is now available from most pharmacies. The generic version contains the same active ingredient as the brand-name Xenical but is more affordable. The average cost of a 3-month supply of Xenical is around $1,200. The over-the-counter version of Xenical generally cost less than the generic version between $10 and $50.
Xenical 120mg Capsules,when used in conjunction with a reduced-calorie diet, can be used for obesity management, including weight loss and weight maintenance.Xenicalworks in your digestive system to block one-third of the fat in the food you eat from being digestedThe daily intake of fat, carbohydrate and protein should be distributed over three main meals.pills can also block the absorption of some vitamins. You may wish to take a multivitamin supplement along with making sure to keep a well-balanced diet, rich in fruit and vegetables.
The active substance isOrlistat. Each capsule contains120 mg of Orlistat
The other ingredients are microcrystalline cellulose (E460), sodium starch glycolate (type A), povidone (E1201), sodium laurilsulfate and talc. The capsule shell consists of gelatine, indigo carmine (E132), titanium dioxide (E171) and edible printing ink.
84 Capsules
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